The project develops methods for in vivo imaging of cellular and subcellular dynamics of the inflammatory glioma microenvironment (innate and adaptive immune responses) and its changes during immunotherapy by MRI and optical methods. This will lead to imaging signatures of glioma response and resistance towards immunotherapies, aid preclinical immunotherapy development and ultimately improve clinical trial monitoring. The visual abstract below shows the aims and planned tasks of the work package.
Based on the findings of work package C03 there was a shift in reserach focus for the second funding period. The follow-up project will analyze imaging characteristics of H3K27M-mutant gliomas and biomarkers for response to neoepitope-specific adoptive T cells therapies in orthotopic patient-derived tumor models and clinical cohorts of adult patients with H3K27M-mutant gliomas (B06).