Research > Focus B
Dr. rer. nat. Theresa Bunse
University Hospital Mannheim, Department of Neurology
The strategic aim of Focus B is to identify cellular, molecular and imaging biomarkers, which allow to refine the use of checkpoint inhibitors in glioma treatment and to develop rational combinatorial therapies to enhance efficacy (B01, B03), to assess the phenotype and efficacy of glioma-rective T cells (B01, B03, B06), to find druggable regulators of tumor-associated macrophages (B01, B03, B04 & B07A), which may sensitize to immune therapy in glioblastoma (B02), and to establish new checkpoints and modes of checkpoint inhibition (B01 & B07A). Focus B will tackle the important question to what extent the mechanisms for negatively influencing the composition of the myeloid tumor compartment and to counteract efficacy of high-dose radiotherapy are similar and may be reverted pharmacologically (B03 & B07A).
Link to: B01: Mechanisms of response and resistance to glioma-specific t cells
B01
Mechanisms of Response and Resistance to glioma-specific t cells
Prof. Dr. med. Michael Platten
University Hospital Mannheim, Department of Neurology
Link to: B02: DNA mis-match repair regulates immune checkpoint blockade therapy in glioblastoma (2019 - 2023)
B02
DNA mis-match repair regulates immune checkpoint blockade therapy in GLIOBLASTOMA (2019-2023)
Hai-Kun Liu, PhD
German Cancer Research Center (DKFZ), Department of Molecular Neurogenetics
Link to: B03: Targeting immunosuppressive programs in isocitrate dehydrogenase mutant gliomas
B03
TARGETING IMMUNSUPPRESSIVE PROGRAMS IN Isocitrate dehydrogenase Mutant GLIOMAS
Dr. rer. nat. Stefan Pusch
University Hospital Heidelberg, Institute for Pathology, Department of Neuropathology
Dr. med. Lukas Bunse
University Hospital Heidelberg, Department of Neurology
Link to: B05: Dissecting the response of glioblastoma and its tumor microenvironment to focused high-dose radiotherapy (2019 - 2023)
Prof. Dr. rer. nat. Christel Herold-Mende
Heidelberg University Hospital, Department of Neurosurgery, Division of Neurosurgical Research
Dr. sc. hum. Rolf Warta
Heidelberg University Hospital, Department of Neurosurgery, Division of Neurosurgical Research
Link to: B05: Dissecting the response of glioblastoma and its tumor microenvironment to focused high-dose radiotherapy (2019 - 2023)
Prof. Dr. med. Marlon Veldwijk
University Medical Center Mannheim, Translational Radiation Oncology, Dept. of Radiation Oncology
Link to: B06: Visualization and characterization of immune responses in H3K27M mutant gliomas
Dr. med. Katharina Sahm
University Medical Center Mannheim, Department of Neurology
PD Dr. med. Michael Breckwoldt, PhD
University Clinic Heidelberg, Department of Neuroradiology