Research > Focus D > Work Packages D02

Data integration, bioinformatics analysis, and data exploration for precision neurooncology

Summary

The aim of this core work package is to maximize synergies between the projects by providing a central infrastructure for data storage, sharing, processing and integrative data analysis. To support precision Neurooncology it will offer a web-based multidimensional data integration and exploration platform that makes the UNITE data accessible and usable for all involved researchers.

Central data repository and processing ensures data quality and facilitates data sharing, data integration and collaborative analyses.

TASK 1 1

An interactive data exploration platform offers multiple visualization and analysis capabilities without requiring programming skills.

TASK 2 1

modular design; all components dockerized
easily exchangeable
easily deployable in different environments
most services written using ASP.NET
communication via standard http protocols
front-end developed on vue.js using the QUASAR framework
PostgreSQL database
indexed by ElasticSearch for efficient data exploration

TASK 3 1

Previous funding period

1st funding period (2019 - 2023)

Principle Investigator

Schlesner, Matthias, Dr. rer. nat.

Schlesner, Matthias, Dr. rer. nat.

Group Leader

DKFZ, Bioinformatics and Omic Data Analytics, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany

CV / Publications Work Package

Members

MEMBERS

UNITE brings together physician-scientists and scientists from the Heidelberg University Hospital, the University Hospital Mannheim, the German Cancer Research Center and the Hochschule Mannheim. By combining the complementary research strengths and technological prowess of all participating principle investigators, UNITE will generate considerable added value towards precision neurooncology.

In total, 31 physician-scientists and scientists from the Heidelberg and Mannheim campus provide complementary expertise for the proposed translational focus of the UNITE research program. This will enable practice changes by translating basic research findings into clinical application. Importantly, the integration of 13 junior work package leaders highlights the career development aspect of the initiative.

A – F

ABDOLLAHI, AMIR, Prof. DR. MED., DR. RER. NAT.

ABDOLLAHI, AMIR, Prof. DR. MED., DR. RER. NAT.

Chair and Division Head

Heidelberg University Hospital, Division of Molecular and Translational Radiation Oncology Heidelberg Ion-Beam Therapy Center (HIT), Im Neuenheimer Feld 450, 69120 Heidelberg, Germany

CV/ Publications Work Package

BAJRAKTARI-SYLEJMANI, GZONA, DR. RER. NAT.

BAJRAKTARI-SYLEJMANI, GZONA, DR. RER. NAT.

Group Leader

Heidelberg University Hospital, Department of Clinical Pharmacology and Pharmacoepidemiology, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany

CV/ Publications Work Package

BENDSZUS, MARTIN, PROF. DR. MED.

BENDSZUS, MARTIN, PROF. DR. MED.

Chair and Head of Department

University Hospital Heidelberg, Department of Neuroradiology, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany

CV / Publikationen Work Package

BERGS, JUDITH, PH.D.

BERGS, JUDITH, PH.D.

Scientific Coordinator

University Hospital Heidelberg, Department of Neurology
Im Neuenheimer Feld 400
69120 Heidelberg, Germany

CV / Publications

BRECKWOLDT, MICHAEL, DR. MED., PH.D

BRECKWOLDT, MICHAEL, DR. MED., PH.D

Clinical Resident / Post Doc

University Hospital Heidelberg, Department of Neuroradiology, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany

CV / Publications Work Package

BUNSE, LUKAS, DR. MED.

BUNSE, LUKAS, DR. MED.

Post Doc

University Hospital Mannheim, Department of Neurology, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany

CV / Publications Work Package

BUNSE, THERESA, NEE SCHUMACHER, DR. RER. NAT.

BUNSE, THERESA, NEE SCHUMACHER, DR. RER. NAT.

Post Doc

Heidelberg University, Mannheim Medical Faculty, University Hospital Mannheim, Department of Neurology, Theodor-Kutzer-Ufer 1-3, 68167 Mannheim, Germany

CV / Publications Work Package

DOKIC, IVANA, DR. RER. NAT.

DOKIC, IVANA, DR. RER. NAT.

Postdoctoral reseacher

Heidelberg University Hospital, Division of Molecular and Translational Radiation Oncology Heidelberg Ion-Beam Therapy Center (HIT), Im Neuenheimer Feld 450, 69120 Heidelberg, Germany

CV / Publications Work Package

ERNST, AURÉLIE, PD Dr. rer. nat.

ERNST, AURÉLIE, PD Dr. rer. nat.

Junior Group Leader

Genome Instability in Tumors, German Cancer Research Center, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany

CV / Publications Work Package

G – L

GOIDTS, VIOLAINE, DR. BIOL. HUM.

GOIDTS, VIOLAINE, DR. BIOL. HUM.

Junior Research Group Leader

German Cancer Research Center, Junior Research Group Brain Tumor Translational Targets, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany

CV / Publications Work Package

HEROLD-MENDE, CHRISTEL, PROF. DR. RER. NAT.

HEROLD-MENDE, CHRISTEL, PROF. DR. RER. NAT.

Professor for Experimental Neurosurgery, Division Head

University Hospital Heidelberg, Department of Neurosurgery, Division of Neurosurgical Research, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany

CV / Publications Work Package

HEUER, SOPHIE, MD

HEUER, SOPHIE, MD

Postdoctoral Researcher / Resident

University Hospital Heidelberg, Department of Neurology, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany

CV / Publications Work Package

HOPF, CARSTEN, PROF. DR. RER. NAT., DIPL.-BIOCHEM.

HOPF, CARSTEN, PROF. DR. RER. NAT., DIPL.-BIOCHEM.

Head of CeMOS

Hochschule Mannheim, Center for Mass Spectrometry and Optical Spectroscopy (CeMOS), Paul-Wittsack-Str. 10, 68163 Mannheim, Germany

CV / Publications Work Package

Jones, David, Prof. Dr.

Jones, David, Prof. Dr.

Group Leader

Hopp Children’s Cancer Center at the NCT Heidelberg (KiTZ) & German Cancer Research Center (DKFZ), Pediatric Glioma Research Group, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany

CV / Publications Work Package

KARREMAN, MATTHIA, PHD

KARREMAN, MATTHIA, PHD

Post Doc

University Hospital Heidelberg, Department of Neurology, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany

CV / Publications Work Package

KESSLER, TOBIAS, DR. MED.

KESSLER, TOBIAS, DR. MED.

Post Doc / Resident

University Hospital Heidelberg, Department of Neurology, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany

CV / Publications Work Package

LIU, HAI-KUN, PhD

LIU, HAI-KUN, PhD

Head of Department

German Cancer Research CenterBrain Cancer Division of Molecular Neurogenetics, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany

CV / Publications Work Package

M – R

Malburg, Cara, M. Sc.

Malburg, Cara, M. Sc.

Project Coordinator

University Hospital Heidelberg, Department of Neurology, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany

CV / Publications

OPITZ, CHRISTIANE, Prof. DR. MED.

OPITZ, CHRISTIANE, Prof. DR. MED.

Division Head

Metabolic Crosstalk in Cancer
German Cancer Research Center
Im Neuenheimer Feld 280,
69120 Heidelberg, Germany

CV / Publications Work Package

PFISTER, STEFAN, PROF. DR. MED.

PFISTER, STEFAN, PROF. DR. MED.

Director Preclinical Research

Hopp Children ́s Cancer Center Heidelberg, German Cancer Research Center (DKFZ), Division of Pediatric Neurooncology & Heidelberg University Hospital, Dep. of Pediatric Hematology and Oncology,
Im Neuenheimer Feld 580, 69120 Heidelberg, Germany

CV / Publications Work Package

PLATTEN, MICHAEL, PROF. DR. MED.

PLATTEN, MICHAEL, PROF. DR. MED.

Chairman/Head

Heidelberg University, Mannheim Medical Faculty, Mannheim University Hospital (UMM), Department of Neurology & DKFZ, Clinical Cooperation Unit Neuroimmunology and Brain Tumor Immunology, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany

CV / Publications Work Package

PUSCH, STEFAN, DR. RER. NAT.

PUSCH, STEFAN, DR. RER. NAT.

Post Doc

University Hospital Heidelberg, Institute of Pathology, Dep. of Neuropathology, Im Neuenheimer Feld 224, 69120 Heidelberg, Germany

CV / Publications Work Package

Ratliff, Miriam, Dr.med., Dipl.-Biol.

Ratliff, Miriam, Dr.med., Dipl.-Biol.

Constultant, Department of Neurosurgery

University Medical Centre Mannheim, Medical Faculty Mannheim, Heidelberg University Theodor-Kutzer-Ufer 1-3, 68167 Mannheim

CV / Publikationen Work Package

REUSS, DAVID E., PD DR. MED.

REUSS, DAVID E., PD DR. MED.

Chief Consultant

University Hospital Heidelberg, Department of Neuropathology, Im Neuenheimer Feld 224, 69120 Heidelberg, Germany

CV / Publications Work Package

S – Z

SAHM, FELIX, PROF. DR. DR. MED.

SAHM, FELIX, PROF. DR. DR. MED.

Head of Div. Molecular Neuropathology

University Hospital Heidelberg, Department of Neuropathology, Im Neuenheimer Feld 224, 69120 Heidelberg, Germany

CV / Publications Work Package

Sahm, Katharina, Dr. med.

Sahm, Katharina, Dr. med.

Clinical Resident / Post Doc

Medical Center Mannheim, Department of Neurology, Theodor-Kutzer-Ufer 1-3, 68167 Mannheim, Germany

CV / Publications Work Package

Schlesner, Matthias, Dr. rer. nat.

Schlesner, Matthias, Dr. rer. nat.

Group Leader

DKFZ, Bioinformatics and Omic Data Analytics, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany

CV / Publications Work Package

TURCAN, SEVIN, PH.D

TURCAN, SEVIN, PH.D

Junior Research Group Leader

University Hospital Heidelberg, Department of Neurology, Im Neuenheimer Feld 460, 69120 Heidelberg, Germany

CV / Publications Work Package

VELDWIJK, MARLON R., PROF. DR.

VELDWIJK, MARLON R., PROF. DR.

Senior scientist, Professor Experimental Radiooncology - Radiobiology

Mannheim Medical Faculty, University of Heidelberg, Dept. of Radiation Oncology, Translational Radiation Oncology, Theodor-Kutzer-Ufer 1-3, D-68167 Mannheim, Germany

CV / Publications Work Package

VENKATARAMANI, DR. MED., DR. RER. NAT.

VENKATARAMANI, DR. MED., DR. RER. NAT.

Post Doc

University Hospital Heidelberg, Department of Neurology, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany

CV / Publications Work Package

VOLLMUTH, PHILIPP, PROF. DR. MED., MBA

VOLLMUTH, PHILIPP, PROF. DR. MED., MBA

Head of Section for Computational Neuroimaging

University Hospital Heidelberg, Department of Neuroradiology, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany

CV / Publications Work Package

VON DEIMLING, ANDREAS, PROF. DR. MED.

VON DEIMLING, ANDREAS, PROF. DR. MED.

Chair / Head of Department

University Hospital Heidelberg, Institute of Pathology, Department of Neuropathology & DKFZ, Clinical Cooperation Unit Neuropathology, Im Neuenheimer Feld 224, 69120 Heidelberg, Germany

CV / Publications Work Package

WARTA, ROLF, DR. SC. HUM.

WARTA, ROLF, DR. SC. HUM.

Post Doc

University Hospital Heidelberg, Division of Neurosurgical Research, Department of Neurosurgery, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany

CV / Publications Work Package

Wick, Wolfgang, Prof. Dr. med.

Wick, Wolfgang, Prof. Dr. med.

UNITE Spokesperson & Chairman

University Hospital Heidelberg, Department of Neurology / Neurooncology & DKFZ, Clinical Cooperation Unit Neurooncology, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany

CV / Publications Work Package

WINKLER, FRANK, PROF. DR. MED.

WINKLER, FRANK, PROF. DR. MED.

Managing senior physician / Full professor for experimental neurooncology

University Hospital Heidelberg, Department of Neurology, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany

CV / Publications Work Package

WITT, OLAF, PROF. DR. MED.

WITT, OLAF, PROF. DR. MED.

Director Translational Program

Hopp Children’s Cancer Center at NCT Heidelberg (KiTZ) Department of Pediatric Oncology, Hematology, Immunology and Pulmonology, University Hospital Heidelberg, Im Neuenheimer Feld 430, 69120 Heidelberg, Germany

CV / Publications Work Package

Zuckermann, Marc, PhD

Zuckermann, Marc, PhD

Group Leader

Hopp Children’s Cancer Center at the NCT Heidelberg (KiTZ), German Cancer Research Center (DKFZ), Division of Pediatric Neurooncology, Preclinical modeling Group, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany

CV / Publications Work Package

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