Research > Focus B > Work Packages B04
In this project, we will characterize the potential immunosuppressive role of myeloid cells for T-cell based immune response in isocitrate dehydrogenase (IDH)1 mutant glioblastomas. We will particularly focus on radio- or chemotherapy-induced changes of the immune tumor microenvironment and how this can be improved pharmacologically. We hypothesize that influencing the composition of the intratumoral myeloid compartment might help to better control pre-existing and therapy-induced immunosuppression. The visual abstract below shows the aims and planned tasks of the work package.