Entries by Maja Zenz

EANO GUIDELINES ON THE DIAGNOSIS AND TREATMENT OF DIFFUSE GLIOMAS OF ADULTHOOD

UNITE  towards clinical implementation In response to major changes in diagnostic algorithms and the publication of mature results from various large clinical trials, the European Association of Neuro-Oncology (EANO) recognized the need to provide updated guidelines for the diagnosis and management of adult patients with diffuse gliomas. Through these evidence-based guidelines, a task force of […]

ArticleIL4I1 IS A METABOLIC IMMUNE CHECKPOINT THAT ACTIVATES THE AHR AND PROMOTES TUMOR PROGRESSION

  Research findings related to UNITE work package C04 Aryl hydrocarbon receptor (AHR) activation by tryptophan (Trp) catabolites enhances tumor malignancy and suppresses anti-tumor immunity. The context specificity of AHR target genes has so far impeded systematic investigation of AHR activity and its upstream enzymes across human cancers. A pan-tissue AHR signature, derived by natural […]